论文部分内容阅读
目的探讨骨转换生化标志物Ⅰ型前胶原氨基端延长肽(PINP)、β-Ⅰ型胶原交联羧基末端肽(β-CTx)与脑卒中瘫痪患者骨质疏松的关系。方法 85例脑卒中瘫痪患者作为研究组,85例肢体活动正常、未合并影响骨代谢疾病的患者作为对照组,两组均行PINP、β-CTx检测,根据早期骨质疏松诊断结果对研究组进行针对性干预治疗,根据腰椎侧位骨小梁骨密度值进行骨质疏松诊断,对比两组腰椎侧位骨小梁骨密度值、骨质疏松发生率、PINP、β-CTx检测结果。结果研究组腰椎侧位骨小梁骨密度值为(0.37±0.12)g/cm~2,明显低于对照组的(0.84±0.16)g/cm~2,差异具有统计学意义(P<0.05)。研究组骨质疏松发生率为45.9%,明显高于对照组的2.4%,差异具有统计学意义(P<0.05)。研究组急性期PINP、β-CTx均明显低于对照组,差异具有统计学意义(P<0.05);治疗后研究组PINP、β-CTx仍明显低于对照组,但与本组急性期对比,差异具有统计学意义(P<0.05)。结论骨转换生化标志物PINP、β-CTx可用于脑卒中瘫痪患者骨质疏松诊断与疗效评估,应用前景广阔。
Objective To investigate the relationship between bone turnover biochemical markers of type Ⅰ procollagen aminopeptyl peptide (PINP) and β-Ⅰ collagen cross-linked carboxyl terminal peptide (β-CTx) and osteoporosis in stroke patients. Methods Eighty-five patients with stroke-induced paralysis were enrolled in the study. Eighty-five patients with normal limb activity were selected as the control group. The patients without bipolar disorder were treated with PINP and β-CTx. According to the diagnostic results of early osteoporosis, According to the BMD of trabecular bone at the lumbar vertebrae, the bone mineral density (BMD), incidence of osteoporosis, PINP and β-CTx were compared between the two groups. Results The BMD of the trabecular bone in the lumbar spine was (0.37 ± 0.12) g / cm ~ 2 in the study group, which was significantly lower than that in the control group (0.84 ± 0.16 g / cm ~ 2, P <0.05 ). The incidence of osteoporosis in the study group was 45.9%, which was significantly higher than that in the control group (2.4%), the difference was statistically significant (P <0.05). The PINP and β-CTx in the acute phase of the study group were significantly lower than those in the control group (P <0.05), while the levels of PINP and β-CTx in the study group were still significantly lower than those in the control group , The difference was statistically significant (P <0.05). Conclusion Bone transformation biochemical markers PINP, β-CTx can be used in the diagnosis and treatment of osteoporosis in patients with stroke paralysis.