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Objective:To observe the relationship of tumor necrosis factor-α(TNF-α)and nitrogenoxide(NO)with the treatment of frequent relapse nephrotic syndrome(FRNS)and to explore the patho-genesis of FRNS and the therapeutic mechanism of Shenkangling(肾康灵,SKL)Granule in children.Methods:Sixty children suffering from FRFRNS were randomly divided into the treated group and controlgroup,30 in each,and the other 30 healthy children were taken as healthy group.The patients were trea-ted with prednisone for a long-term course,and those with no effect or partial effect shown were treatedwith additional Tripterygium or Cytoxan in the control group,while in the treated group patients weretreated with prednisone and additional SKL.The two groups were compared as to their changes of TNF-α,NO before and after treatment,and the relapses after treatment.Results:The levels of TNF-α and NO inthe sick children before treatment were markedly higher than those afer treatment and normal group(P<0.01).The positive correlation
Objective: To observe the relationship of tumor necrosis factor-alpha (TNF-alpha) and nitrogenoxide (NO) with the treatment of frequent relapse nephrotic syndrome (FRNS) and to explore the patho-genesis of FRNS and the therapeutic mechanism of Shenkangling Kang Ling, SKL) Granule in children. Methods: Sixty children suffering from FRFRNS were randomly divided into the treated group and control group, 30 in each, and the other 30 healthy children were taken as healthy group. The patients were trea-ted with prednisone for a long-term course, and those with no effect or partial effect shown were treated with additional Tripterygium or Cytoxan in the control group, while in the treated group patients weretreated with prednisone and additional SKL. The two groups were compared as to their changes of TNF-α, NO before and after treatment, and the relapses after treatment. Results: The levels of TNF-α and NO inthe sick children before treatment were markedly higher than those afer treatment and normal group (P <0.01). positive correlation