概述定义类风湿因子(RF)是针对 IgG的 Fc 片断的抗体。而针对 IgG 的轻链、Fab、F(ab′)_2片断以及针对其它免疫球蛋白的Fc 片断的多种抗免疫球蛋白抗体,虽然也出现于类风湿性关节炎(RA)病人的血清中,但均不是 RF。发现与命名 1937年 Frik Waaler 作补体消耗型梅毒诊断试验时发现有1份血清不使兔抗羊红细胞抗体所致敏的羊红细胞发生溶血而是出现凝集,并证明此凝集因子不是红细胞凝集素,也不是胶固素,该因子见 Overview Definition The rheumatoid factor (RF) is an antibody against the Fc fragment of IgG. While a variety of anti-immunoglobulin antibodies against the light chain of IgG, Fab, F (ab ’) _2, and the Fc fragment against other immunoglobulins, are also present in the serum of patients with rheumatoid arthritis (RA) , But neither is RF. Discovery and naming 1937 Frik Waaler for complement consumptive type syphilis diagnosis test found that 1 serum does not make rabbit anti-sheep erythrocyte antibody sensitized sheep erythrocyte hemolysis but agglutination and prove that this coagulation factor is not a hemagglutinin, Nor glucocorticoids, see the factor