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目的 探讨鼻咽癌患者外周血细胞免疫功能与临床期别的关系。方法 采用流式细胞仪检测３２４ 例鼻咽癌患者外周血５ 种细胞免疫表型，并与１００ 例健康人进行比较。其中Ⅰ期８ 例，Ⅱ期１１１ 例，Ⅲ期１４５ 例，Ⅳ期６０例。结果 鼻咽癌患者的 Ｃ Ｄ３、 Ｃ Ｄ４ 下降， Ｃ Ｄ８ 升高， Ｃ Ｄ４／ Ｃ Ｄ８ 比例下降，与正常人比较 Ｐ＜ ０．０５。 Ｃ Ｄ１９ 的改变亦初步显示其临床价值。结论 Ｎ Ｐ Ｃ患者的免疫功能降低以 Ｃ Ｄ４／ Ｃ Ｄ８ 的下降最明显。
Objective To investigate the relationship between peripheral blood cellular immune function and clinical stage in patients with nasopharyngeal carcinoma. Methods Flow cytometry was used to detect the immunocytochemical phenotypes of 5 kinds of peripheral blood in 324 patients with nasopharyngeal carcinoma and compared with 100 healthy subjects. There were 8 cases in stage Ⅰ, 111 cases in stage Ⅱ, 145 cases in stage Ⅲ and 60 cases in stage Ⅳ. Results The proportion of C D3, C D4 decreased, C D8 increased, and C D4 / C D8 decreased in patients with nasopharyngeal carcinoma, P <0.05 compared with normal subjects. The change of C D19 also initially showed its clinical value. Conclusion The decrease of immune function in patients with N P C was the most obvious in C D4 / C D8.