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目的探讨结肠黑变病的病因及其与结肠肿瘤的关系。方法对38例结肠黑变病患者的临床资料、镜下表现及病理进行回顾性分析。结果长期服泻药患者25例(65.8%),未有明确服泻药史患者12例(31.6%),不详1例;结肠癌患者0例,结肠息肉患者8例,病理示管状腺瘤患者6例,混合型患者2例。结论结肠黑变病病因可能与细胞凋亡有关;结肠黑变病与结肠肿瘤有密切关系。
Objective To investigate the etiology of colorectal melanosis and its relationship with colorectal neoplasms. Methods The clinical data, microscopic findings and pathology of 38 cases of melanosis patients were retrospectively analyzed. Results There were 25 patients (65.8%) who laxed for a long time, 12 patients (31.6%) did not have definite history of laxatives and 1 patient was unknown. There were 0 cases of colon cancer, 8 cases of colon polyps, 6 cases of pathological adenoma , Mixed patients in 2 cases. Conclusions The cause of colonic melanosis may be related to cell apoptosis. Colitis mellitus is closely related to colon cancer.