目的　观察阿托伐他汀对脑梗死病人血脂及载脂蛋白的影响。方法　选取 50例脑梗死合并高血脂症的病人随机分为两组 ,阿托伐他汀组 2 5例 ,10mg/d口服 ;辛伐他汀组 2 5例 ,10mg/d口服。 结果　治疗 3周后两组病人的TC、TG、LDL C、ApoB均有下降 ,阿托伐他汀组各指标的下降幅度大于辛伐他汀组 ,其中LDL C、ApoB的降低幅度两组相比差异有显著意义 (P <0 0 5)。 结论　阿托伐他汀是一安全、高效的降脂药物 ,可在短时间内使血脂达标 ,减少脑血管病的危险因素 Objective To observe the effect of atorvastatin on blood lipids and apolipoproteins in patients with cerebral infarction. Methods Fifty patients with cerebral infarction complicated with hyperlipidemia were randomly divided into two groups: 25 patients in the atorvastatin group and 10 mg / d orally in the atorvastatin group; 25 patients in the simvastatin group and 10 mg / d orally. Results The levels of TC, TG, LDL C and ApoB decreased in both groups after 3 weeks of treatment, and decreased more significantly in atorvastatin group than in simvastatin group. The decrease of LDL C and ApoB in the two groups were significantly different Significant (P <0 05). Conclusions Atorvastatin is a safe and effective antihyperlipidemic drug, which can make the blood lipid achieve the goal and reduce the risk factors of cerebrovascular disease in a short time