论文部分内容阅读
目的探讨辅助性T细胞17(Th17)和调节性T细胞(Treg)在子宫内膜癌中的表达及意义。方法将上海市第一人民医院宝山分院2014-2015年收治的30例子宫内膜癌患者列为研究组,38例子宫肌瘤患者列为对照组。应用免疫组织化学染色法,分别检测两组患者标本Th17和Treg细胞表达情况。结果研究组Th17和Treg的表达较对照组明显升高(P<0.05),研究组中,进展期、中低分化组Th17和Treg表达显著高于早期、高分化组,差异有统计学意义(P<0.05),Th17和Treg之间有关联,但在子宫内膜癌进展期关联性差。结论 Th17和Treg参与子宫内膜癌的发生发展,随着肿瘤进展,Treg/Th17存在失衡现象。
Objective To investigate the expression and significance of helper T cells (Th17) and regulatory T cells (Tregs) in endometrial carcinoma. Methods Thirty patients with endometrial cancer who were admitted to Baoshan Branch of Shanghai First People’s Hospital from 2014 to 2015 were selected as the research group and 38 patients with uterine fibroids as the control group. Immunohistochemical staining was used to detect the expression of Th17 and Treg cells in two groups of patients. Results The expression of Th17 and Treg in the study group was significantly higher than that in the control group (P <0.05). The expression of Th17 and Treg in the advanced, moderately poorly differentiated group was significantly higher than that in the early and well differentiated group (P <0.05), and the difference was statistically significant P <0.05). There was a relationship between Th17 and Treg, but poorly correlated with the progression of endometrial cancer. Conclusion Th17 and Treg are involved in the development of endometrial carcinoma. As the tumor progresses, imbalance of Treg / Th17 exists.