Rabies virus(RABV)of the rhabdoviridae family is a prototype neurotropic virus that causes a fatal disease,and is still a major risk mostly in developing countries.A key step in the RABV infection process is its arrival into the central nervous system(CNS),for which it uses the cellular transport machinery.Neurons are irregular cells with a specialized anatomy,and often extend lengthy axons that may span over a meter long.In infected organisms,RABV virions enter the neuron periphery at the area of a bite and must overcome great distances in order Rabies virus (RABV) of the rhabdoviridae family is a prototype neurotropic virus that causes a fatal disease, and is still a major risk mostly in developing countries. A key step in the RABV infection process is its arrival into the central nervous system (CNS) , for which it uses the cellular transport machinery. Neurons are irregular cells with a specialized anatomy, and often extend lengthy axons that may span over a meter long. infected organisms, RABV virions enter the neuron periphery at the area of ​​a bite and must overcome great distances in order