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目的 探讨先天畸形与致畸危险因素的关系。方法 对先天畸形儿进行家族史、孕期不利因素史等全面调查分析。结果 先天畸形与畸形家族史、孕早期母病毒感染、接触有害理化物质、情绪差、用药、父母嗜烟酒及环境污染等有关(P <0 0 0 1)。与孕中后期不利因素无明显关系 (P >0 0 5 )。结论 先天畸形与畸形家族史及孕早期不利因素有关。提示应引起重视并加以干预
Objective To explore the relationship between congenital malformation and teratogenic risk factors. Methods A comprehensive survey of family history of congenital malformations, unfavorable factors during pregnancy and so on. Results Congenital malformations were associated with familial history of deformity, early motherhood viral infection, exposure to harmful substances, poor mood, medication, alcohol abuse and alcohol abuse, and environmental pollution (P <0.01). There was no significant relationship between adverse factors in the second trimester and the second trimester (P> 0.05). Conclusion Congenital malformations and deformity family history and adverse factors in early pregnancy. Tips should draw attention and intervene