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慢性盆腔炎是妇科的常见、多发病。它常为混合性病原体引起的组织炎性反应 ,其免疫病理损伤是本病慢性进展的主要原因。免疫因素参与其病变过程[1] ,细胞粘附分子 (ICAM - 1)诱导了慢性炎症的组织损伤及局部组织慢性纤维化过程[2、3 ] 。粘附分子可以促进白细胞浸润至炎症部位[4] 。本项研究在建立慢性盆腔炎动物模型的基础上 ,探讨了慢性盆腔炎与ICAM - 1的关系、中药炎克宁冲剂对慢性盆腔炎局部组织ICAM - 1含量的影响 ,采用免疫组化法对模型细胞粘附分子 (ICAM - 1)进行了测定。结果表明 :炎克宁冲剂明显降低局部组织ICAM - 1含量 ,使其恢复正常水平。提示 :中药炎克宁冲剂是防治本病的有效药物 ,有深入研究、开发利用的价值。
Chronic pelvic inflammatory disease is a gynecological common, frequently-occurring disease. It is often mixed pathogens caused by tissue inflammatory response, the immune pathological damage is the main reason for the chronic progression of the disease. Immune factors involved in the process of the disease [1], cell adhesion molecule (ICAM - 1) induced chronic inflammatory tissue damage and local tissue of chronic fibrosis [2,3]. Adhesion molecules can promote leukocyte infiltration to the site of inflammation [4]. In this study, the relationship between chronic pelvic inflammatory disease and ICAM - 1 was explored on the basis of establishing an animal model of chronic pelvic inflammatory disease. The effect of Yankening Granule on the content of ICAM - 1 in the local tissue of chronic pelvic inflammatory disease was studied. Immunohistochemistry Model cell adhesion molecule (ICAM - 1) was determined. The results showed that Yankening Granules could significantly reduce the content of ICAM - 1 in local tissues and restore normal levels of ICAM - 1. Tip: Chinese medicine Yan Ke Ning granules is an effective drug for the prevention and treatment of this disease, with in-depth research, development and utilization of value.