【摘 要】
：
为了检测初治急性髓系白血病(AML)细胞CD34+抗原的表达,并分析其与预后的关系,应用间接免疫荧光法检测了238例AML患者。结果表明:238例AML中CD34阳性表达者有92例,占38.7%。
【机 构】
：
新疆医科大学第一附属医院血液科、新疆血液病研究所,上海市杨浦区中心医院内科,新疆医科大学第一附属医院血液科、新疆血液病研究所,新疆医科大学第一附属医院血液科、新疆血液病研究所,新疆医科大学第一附属医院
论文部分内容阅读
为了检测初治急性髓系白血病(AML)细胞CD34+抗原的表达,并分析其与预后的关系,应用间接免疫荧光法检测了238例AML患者。结果表明:238例AML中CD34阳性表达者有92例,占38.7%。除M3无CD34阳性表达外,CD34+表达与FAB亚型M0、M1有关;CD34+组完全缓解率为32%,明显低于CD34-组的61%;除淋系抗原CD7在CD34+组表达明显增高外,其它淋系抗原表达在两组间无差异(P<0.05)。结论:有CD34+表达的AML患者预后差、CR率低,检测CD34表达对判断AML疗效有一定价值。
To detect the expression of CD34 + antigen in newly diagnosed acute myeloid leukemia (AML) cells and to analyze its relationship with prognosis, 238 AML patients were detected by indirect immunofluorescence assay. The results showed that there were 92 cases of CD34 positive expression in 238 cases of AML, accounting for 38.7%. In addition to M3 without CD34 positive expression, CD34 + expression and FAB subtypes M0, M1; CD34 + group complete remission rate was 32%, significantly lower than CD34- group of 61%; except leukemia cells CD7 in CD34 + group was significantly higher expression , Other lymphoid antigen expression was no difference between the two groups (P <0.05). Conclusion: AML patients with CD34 + expression have poor prognosis and low CR rate. Detection of CD34 expression may be of value in judging the efficacy of AML.
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