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许多人认为,氯林肯霉素(Clindamycin)是治疗痤疮很有希望的抗菌素,是四环素最好的替换药,尤适用于炎症重的患者。作者为了进一步探讨小剂量长期服用该药的安全性,选择60例严重的脓疱性或囊肿性痤疮患者(性别:男13,女47;年龄:16～34岁),定期观察氯林肯霉素治疗的不良反应。开始剂量150毫克,每日二次,病情得到控制后(部分患者)减为每日一次。平均疗程3.8个月(18例在6个月以上),平均服药总量37克(16例超过50克)。结果:58例(96.6％)无不良反应,未发现过敏反应、光过敏反应、串珠菌病或恶心等。仅二例(3.4％)在服药过程中有轻度腹泻,停药24～48小时后即好转,不需其他处理。本药治疗痤疮愈趋普遍的原因是,对其作用机理有一定的实验根据,在临床使用方面较四环素有
Many believe that Clindamycin is a promising antibiotic for the treatment of acne and is the best replacement for tetracycline and is especially suitable for patients with severe inflammation. In order to further explore the safety of small doses of long-term use of the drug, select 60 cases of severe pustular or cystic acne patients (sex: male 13, female 47; age: 16 to 34 years old), regular observation clindamycin Adverse reactions to treatment. The initial dose of 150 mg, twice daily, after the condition is controlled (some patients) reduced to once daily. The average course of treatment was 3.8 months (18 cases over 6 months), with an average of 37 grams (16 cases over 50 grams). Results: There were no adverse reactions in 58 cases (96.6%), no allergic reactions, light allergic reactions, streptococcus or nausea. Only two cases (3.4%) had mild diarrhea during medication. After stopping for 24 to 48 hours, the treatment improved without any other treatment. The drug acne treatment more common reason is that its mechanism of action has some experimental basis, in clinical use than tetracycline