绝大多数恶性肿瘤中存在凋亡信号的缺失,从而促使细胞恶性增生,导致肿瘤的发生。其中的机制除了经典的bcl-2蛋白过表达直接或间接抑制凋亡以外[1],另外一组凋亡调节分子在1993年Crool等[2]为了鉴定病毒感染的调节分子过程中,从杆状病毒中发现,即凋亡蛋白抑制剂(inhibitor ofapo The vast majority of malignant tumors exist in the absence of apoptotic signals, thereby promoting malignant proliferation of cells, leading to the occurrence of tumors. In addition to the classical bcl-2 protein overexpression directly or indirectly inhibit apoptosis [1], another group of apoptosis regulatory molecules in 1993, Crool et al [2] in order to identify the regulatory molecules of viral infection, from the rod The virus found in the virus, namely inhibitor of apoptosis (inhibitor ofapo