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EB病毒(EBV)是一种普遍存在的致癌病毒,是高度相关的淋巴和上皮肿瘤的来源和发展,包括伯基特淋巴瘤和鼻咽癌(NPC)等,EBV基因几乎可以在所有细胞中。EBV感染通常与少数潜伏病毒功能的蛋白质表达,包括潜伏膜蛋白LMP1和LMP2A等和巴尔核抗原1(EBNA1)。LMP1是肿瘤坏死因子受体超家族的成员,被认为是EBV的主要致瘤蛋白。在EB病毒中通过2个C末端结构域编码基因蛋白LMP1信号来驱动细胞生长,存活和转化。LMP1蛋白目前是惟一已被证实的EB病毒的癌基因,LMP1的表达参与了肿瘤的发生与发展,是目前癌症方面研究的重点。
Epstein-Barr virus (EBV), a ubiquitous oncogenic virus, is a source and development of highly associated lymphoid and epithelial tumors, including Burkitt’s lymphoma and nasopharyngeal carcinoma (NPC). The EBV gene is found in almost all cells . EBV infections are often expressed with a few proteins that are latent for viral functions, including the latent membrane proteins LMP1 and LMP2A, and Barrna antigen 1 (EBNA1). LMP1 is a member of the tumor necrosis factor receptor superfamily and is considered the major oncogenic protein of EBV. The Epstein-Barr virus encodes the gene protein LMP1 signaling through two C-terminal domains to drive cell growth, survival and transformation. Currently, LMP1 protein is the only confirmed oncogene of Epstein-Barr virus. The expression of LMP1 is involved in the development and progression of tumors, which is the focus of cancer research.