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目的探讨环磷腺苷葡胺治疗老年充血性心力衰竭的临床疗效。方法选取2014年1月—2015年10月淮安市楚州中医院收治的老年充血性心力衰竭患者60例,按照入院治疗时间顺序将患者分为对照组与研究组,各30例。对照组患者予以西医常规治疗,研究组患者在对照组治疗基础上予以环磷腺普葡胺治疗,两组患者均治疗10d。比较两组患者临床疗效、超声心动指标〔左室射血分数(LVEF)、心排血指数(CI)、每搏输出量(SV)、血压(BP)、心搏出量(CO)、心率(HR)〕及药物不良反应发生情况。结果研究组患者总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者超声心动指标比较,差异无统计学意义(P>0.05);治疗后研究组患者LVEF、CI水平高于对照组,差异有统计学意义(P<0.05);治疗后两组患者SV、BP、CO、HR水平比较,差异无统计学意义(P>0.05);治疗后两组患者HR、BP水平低于治疗前,LVEF、SV、CO、CI高于治疗前,差异有统计学意义(P<0.05)。两组患者在治疗过程中均未出现严重不良反应。结论在西医常规治疗老年充血性心力衰竭基础上,辅以环磷腺苷葡胺可提高患者的治疗效果。
Objective To investigate the clinical efficacy of cyclic adenosine monophosphate (AMPA) in the treatment of congestive heart failure in the elderly. Methods Sixty elderly patients with congestive heart failure admitted to Chuzhou Chinese Medicine Hospital of Huai’an City from January 2014 to October 2015 were selected and divided into control group and study group according to the time sequence of admission. Patients in the control group were treated routinely with Western medicine. Patients in the study group were given cyclophosphamide orally with puerarin on the basis of the control group, and both groups were treated for 10 days. The clinical efficacy, echocardiographic parameters (left ventricular ejection fraction, left ventricular ejection fraction, left ventricular ejection fraction, left ventricular ejection fraction, SV, BP, (HR)] and adverse drug reactions occurred. Results The total effective rate of study group was higher than that of control group, the difference was statistically significant (P <0.05). There was no significant difference in echocardiographic parameters between the two groups before treatment (P> 0.05). After treatment, the levels of LVEF and CI in the study group were significantly higher than those in the control group (P <0.05) There were no significant differences in SV, BP, CO and HR between the two groups (P> 0.05). After treatment, the levels of HR and BP in both groups were lower than those before treatment, and the levels of LVEF, SV, CO and CI were higher than those before treatment Statistical significance (P <0.05). Two groups of patients in the course of treatment did not appear serious adverse reactions. Conclusion Western conventional therapy based on elderly congestive heart failure, supplemented with cyclic AMP adenosine monophosphate can improve the therapeutic effect of patients.