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目的:探讨人乳头瘤病毒(HPV)分型检测在维吾尔族和汉族宫颈癌机会性筛查中的意义。方法:采用宫颈细胞学检查和HPV分型检测对1 140例患者行宫颈癌机会性筛查,共438例患者在阴道镜下行宫颈活检,评价HPV分型检测的诊断价值。结果:1 140例HPV总感染率为30.3%(345/1 140),检出的高危型HPV主要型别依次为HPV16、58、52、18、45型。汉族HPV52型感染率高于维吾尔族,差异具有统计学意义(χ2=8.737,P=0.003)。1 140例患者中单一感染率为22.4%(255/1 140),多重感染率为6.1%(69/1 140),HPV分型检测诊断宫颈病变的灵敏度为86.4%(209/242)、特异度为24.5%(48/196)、阳性预测值为58.5%(209/357)、阴性预测值为59.3%(48/81)。结论:维吾尔族和汉族HPV感染型别各有其自身特点,HPV分型检测对宫颈病变的诊断有重要价值。
Objective: To investigate the significance of human papillomavirus (HPV) typing in screening opportunistic cervical cancer in Uighur and Han nationality. Methods: A total of 1 140 cases of cervical cancer were screened by cervical cytology and HPV typing. A total of 438 cervical biopsies were performed under colposcopy to evaluate the diagnostic value of HPV typing. Results: The total infection rate of 1 140 cases was 30.3% (345/1 140). The main types of high-risk HPV were HPV16,58,52,18,45. The HPV52 infection rate of Han nationality was higher than that of Uyghur nationality (χ2 = 8.737, P = 0.003). The single infection rate was 22.4% (255/1 140) in 1 140 patients, and the multiple infection rate was 6.1% (69/1 140). The sensitivity of HPV typing in diagnosing cervical lesions was 86.4% (209/242) Degree was 24.5% (48/196), positive predictive value was 58.5% (209/357), and negative predictive value was 59.3% (48/81). Conclusion: The genotypes of HPV infection in Uygur and Han each have their own characteristics. HPV genotyping has important value in the diagnosis of cervical lesions.