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目的:对红花的普通粉体和不同粒径的超微粉体中有效成分羟基红花黄色素A、山柰素进行溶出度比较试验,为红花超微粉体的应用与粒径控制提供试验依据。方法:桨状搅拌法,用高效液相法测定其含量。结果:红花普通粉体与3种超微粉体(D50分别为14.71、22.42、和35.33μm)羟基红花黄色素A的溶出量分别为1.99%、2.20%、2.23%和2.25%,山柰素溶出量分别为0.16%、0.20%、0.21%和0.21%。红花普通粉体与3种超微粉体羟基红花黄色素A的T50、Td为别为14.66、61.21,6.97、30.67,4.281、9.28,3.63、15.31 min;红花普通粉体与3种超微粉体山柰素的T50、Td为别为36.74、670.96,17.17、417.36,12.36、200.72,10.911、60.05 min。结论:3种红花超微粉体有效成分的溶出量明显高于普通粉体,溶出速度明显快于普通粉体,且随着超微粉体粒径减小,有效成份溶的出速率加快。
OBJECTIVE: To compare the dissolution test of safflower yellow pigment A and kaempferol, the effective components of safflower powder and ultrafine powder with different particle sizes, and to control the application and particle size of safflower ultrafine powder. Provide test basis. Method: Paddle stirring method, its content was determined by HPLC. RESULTS: The elution rates of safflower powder and three ultrafine powders (D50 were 14.71, 22.42, and 35.33 μm, respectively) of hydroxysafflor yellow A were 1.99%, 2.20%, 2.23%, and 2.25%, respectively. The release of alizarin was 0.16%, 0.20%, 0.21% and 0.21%, respectively. The T50 and Td of common safflower powder and three kinds of ultrafine powder hydroxysafflor yellow A were 14.66, 61.21, 6.97, 30.67, 4.281, 9.28, 3.63 and 15.31 min; the common powder of safflower and 3 kinds of The T50 and Td of the ultrafine powder kaempferol were 36.74, 670.96, 17.17, 417.36, 12.36, 200.72, 10.91, 60.05 min. Conclusion: The dissolution of the active components of the three kinds of safflower ultrafine powders is obviously higher than that of common powders. The dissolution rate is obviously faster than that of common powders. With the decrease of the ultrafine powder particle size, the dissolution rate of active ingredients is accelerated. .