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目的观察经冠状动脉介入治疗(PCI)治疗对肿瘤坏死因子α(TNF-α)及基质金属蛋白酶-9(MMP-9)的影响。方法纳入存在单支病变经PCI治疗的冠心病患者60例,同期经冠状动脉造影证实冠状动脉正常者30例作为对照组。分析两组冠心病危险因素的合并比例,采用酶联免疫吸附法分别检测入选患者冠状动脉介入治疗前后TNF-α和MMP-9水平并进行组间比较。结果①有冠状动脉狭窄需行PCI治疗患者存在冠心病危险因素的比例高于对照组;②PCI组患者术后血浆TNF-α显著高于术前[(19.89±5.41)ng/mLvs.(15.78±5.34)ng/ml,P<0.01],对照组冠状动脉造影术后TNF-α与术前相比差异无统计学意义[(13.76±5.54)ng/mLvs.(12.48±5.12)ng/mL,P>0.05];③PCI组患者术后血浆MMP-9显著高于术前[(21.97±5.93)mg/Lvs.(18.65±5.72)mg/L,P<0.01],对照组冠脉造影术后MMP-9与术前相比差异无统计学意义[(16.21±5.33)mg/Lvs.(15.31±5.21)mg/L,P>0.05]。结论需PCI治疗的患者冠心病危险因素高于无冠脉狭窄者,冠脉介入治疗较冠脉造影可造成冠心病患者血浆TNF-α及MMP-9水平明显升高,可能与术后支架再狭窄有关。
Objective To observe the effect of percutaneous coronary intervention (PCI) on tumor necrosis factor α (TNF-α) and matrix metalloproteinase-9 (MMP-9). Methods Sixty coronary artery disease patients with single vessel disease undergoing PCI were included in the study. Thirty patients with normal coronary artery confirmed by coronary angiography during the same period were selected as the control group. The combined proportion of risk factors of coronary heart disease was analyzed. The levels of TNF-α and MMP-9 in the patients before and after coronary intervention were detected by enzyme-linked immunosorbent assay and compared between groups. Results ① There was a higher risk of coronary heart disease in patients with coronary artery stenosis than those in the control group. ② The postoperative plasma levels of TNF-α in PCI group were significantly higher than those in preoperative [(19.89 ± 5.41) ng / mL vs (15.78 ± (13.36 ± 5.54) ng / mL vs (12.48 ± 5.12) ng / mL, respectively. There was no significant difference between the two groups in the control group (P> 0.05) P> 0.05] .③The plasma levels of MMP-9 in PCI group were significantly higher than those before PCI [(21.97 ± 5.93) mg / L vs (18.65 ± 5.72) mg / L, P <0.01] The difference of MMP-9 between the two groups was not statistically significant [(16.21 ± 5.33) mg / L vs (15.31 ± 5.21) mg / L, P> 0.05]. Conclusions The risk factors of coronary heart disease in patients undergoing PCI are higher than those without coronary artery stenosis. Coronary angiography can significantly increase the levels of plasma TNF-α and MMP-9 in patients with coronary heart disease, which may be related to postoperative stent Narrowly related.