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35名弥漫性甲状腺肿伴甲状腺机能亢进的患者和10名健康人的染色体研究结果表明:(1)患者的染色体结构畸变率显著高于对照组健康人者(P<0.01),结构畸变以单体断裂为主;(2)患者的染色体畸变与性别及硫脲类抗甲亢药物的治疗剂量无关;(3)伴突眼症者和不伴突眼症者之间的染色体结构畸变率有显著性差异,前者高于后者(P<0.05);(4)患者的染色体结构畸变累及多条染色体。
Chromosomal analysis of 35 patients with diffuse goiter and hyperthyroidism and 10 healthy subjects showed that: (1) The chromosomal aberration rate of the patients was significantly higher than that of healthy controls (P <0.01) Body fracture; (2) the patient’s chromosome aberration and gender and the anti-hyperthyroidism thiourea treatment dose has nothing to do; (3) with and without exophthalmos patients with chromosomal structural aberration rate was significant The former was higher than the latter (P <0.05). (4) The chromosomal aberrations of the patients involved multiple chromosomes.