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目的:探讨血清促红细胞生成素(EPO)在噬血细胞综合征(HPS)患者中的表达水平及临床意义。方法:收集22例HPS患者及15例健康人血清,分别采用酶联免疫吸附(ELISA)方法检测其血清EPO水平,并与各实验室检查指标进行相关性分析。结果:HPS患者组血清EPO水平显著高于健康对照组,差异有统计学意义(P<0.01),感染相关性HPS患者和肿瘤相关性HPS患者血清EPO水平差异无统计学意义(P>0.05)。检测HPS患者血清EPO水平与采血当日红细胞、血红蛋白、血肌酐、尿素氮、三酰甘油、纤维蛋白原、铁蛋白、NK细胞活性、sCD25水平的相关性,发现其与铁蛋白水平呈正相关关系,与其他各项实验室指标均无相关性。结论:HPS患者血清EPO升高可能与贫血、肿瘤有关,但由于炎性因子抑制了EPO对贫血反应的敏感性,所以与血红蛋白之间并无相关关系。EPO在疾病的发生、发展中可能起到一定作用。
Objective: To investigate the expression and clinical significance of serum erythropoietin (EPO) in patients with hemophagocytic syndrome (HPS). Methods: Serum levels of 22 HPS patients and 15 healthy volunteers were collected. Serum levels of EPO were detected by enzyme-linked immunosorbent assay (ELISA), and the correlations were also analyzed with laboratory indexes. Results: The serum levels of EPO in HPS patients were significantly higher than those in healthy controls (P <0.01). There was no significant difference in serum EPO levels between HPS patients with HPS and those with HPS (P> 0.05) . The level of serum erythrocyte, hemoglobin, serum creatinine, urea nitrogen, triacylglycerol, fibrinogen, ferritin, NK cell activity and sCD25 level in HPS patients were detected by the correlation between serum EPO levels and ferritin levels. There is no correlation with other laboratory indicators. Conclusions: Elevated serum levels of EPO may be related to anemia and tumor in HPS patients. However, there is no correlation between hemoglobin and EPO because they inhibit the sensitivity of EPO to anemia. EPO may play a role in the occurrence and development of the disease.