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目的观察阿托伐他汀对急性心肌梗死(AMI)冠脉介入治疗(PCI)中心肌灌注水平的影响。方法将82例急性心肌梗死患者随机分为观察组和对照组各41例,2组患者均给予常规的PCI和急性心肌梗死治疗,观察组术前加服阿托伐他汀80 mg。观察2组术后即刻TIMI帧数(CTFC)、冠状动脉血流速度、心肌灌注显像积分及血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白T(cTnT)水平。结果观察组校正的TIMI帧数、心肌灌注显像积分、CK-MB以及cTnT水平明显低于对照组(P均<0.05),冠状动脉血流速度高于对照组(P<0.05)。结论术前紧急服用阿托伐他汀可以改善急性心肌梗死PCI术患者冠状动脉血流以及心肌灌注水平,值得在临床上推广应用。
Objective To observe the effect of atorvastatin on myocardial perfusion in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Methods 82 patients with acute myocardial infarction were randomly divided into the observation group and the control group of 41 cases, two groups were given conventional PCI and acute myocardial infarction treatment, the observation group before taking atorvastatin 80 mg. The TIMI frame count (CTFC), coronary flow velocity, myocardial perfusion imaging score, serum creatine kinase (CK), creatine kinase (CK-MB), cardiac troponin T (cTnT) levels. Results The corrected TIMI frames, myocardial perfusion imaging scores, CK-MB and cTnT levels in the observation group were significantly lower than those in the control group (all P <0.05). The coronary flow velocity was higher in the observation group than in the control group (P <0.05). Conclusion Preoperative emergency use of atorvastatin can improve coronary blood flow and myocardial perfusion in patients with acute myocardial infarction and is worth popularizing in clinic.