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热性惊厥是小儿时期最常见的惊厥性疾病,儿童期患病率3%～4%,约50%的患儿会在今后发热时再次或多次发生热性惊厥。反复热性惊厥过程中,氨酪酸(GABA)作为中枢神经系统重要的抑制性神经递质在海马区有显著改变,并且GABA与气体信号分子一氧化氮、一氧化碳及硫化氢相互调节,平衡兴奋/抑制状态。了解GABA在反复热性惊厥中的变化,能更好地理解其在脑损伤中的作用。
Convulsive febrile seizures are the most common convulsive diseases in infancy, the prevalence of childhood 3% to 4%, about 50% of children in the future fever again or more febrile seizures. During repeated febrile seizures, GABA significantly changes in the hippocampus as an important inhibitory neurotransmitter in the central nervous system, and GABA regulates the signaling molecules nitric oxide, carbon monoxide and hydrogen sulfide to balance the excitement / Inhibit the state. Understanding the changes in GABA during recurrent febrile seizures provides a better understanding of its role in brain injury.