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目的:探讨CD22和CD79b在慢性淋巴细胞白血病(CLL)B细胞上的表达情况。方法:共收集106例初诊的CLL患者,异硫氰酸酯(FITC)标记的CD22和CD79b抗体标记细胞,流式细胞仪(FCM)检测B淋巴细胞CD22和CD79b的表达;同时以34例健康者做对照。结果:部分CLL患者B细胞表达CD22和CD79b,但是CD22和CD79b的荧光强度明显低于正常者。结论:CLL患者B细胞可以表达CD22和CD79b,但是CD22和CD79b表达特点为弱表达。
Objective: To investigate the expression of CD22 and CD79b on chronic lymphocytic leukemia (CLL) B cells. METHODS: A total of 106 newly diagnosed CLL patients were enrolled and labeled with isothiocyanate (FITC) labeled CD22 and CD79b antibody. Flow cytometry (FCM) was used to detect the expression of CD22 and CD79b in B lymphocytes. Meanwhile, 34 healthy controls Contrast. Results: B cells in some CLL patients expressed CD22 and CD79b, but the fluorescence intensity of CD22 and CD79b was significantly lower than that of normal subjects. Conclusion: B cells from CLL patients can express CD22 and CD79b, but CD22 and CD79b expression is weakly expressed.