目的　了解聚吡咯 (Polypyrrole ,PP)材料与周围神经组织的生物相容性 ,为PP作神经桥接物进行缺损神经桥接再生试验提供实验依据。　方法　运用电化学氧化法合成导电玻璃、硅胶管上的PP膜。取新生大鼠的坐骨神经与PP材料联合培养 ,倒置显微镜与扫描电镜形态观察。结果　电化学氧化法合成的PP导电性能均较好 ;导电玻璃的PP膜表面光滑 ,微孔较小 ;硅胶管内壁膜除同导电玻璃外 ,还可成絮状表面 ,微孔交织成网。神经组织的雪旺细胞在平滑的PP表面生长迁移良好 ,而絮状表面相对差。　结论　体外联合培养结果提示 ,PP与大鼠周围神经组织有较好的生物相容性 ,表面光滑的PP更易使神经组织的细胞生长迁移 Objective To understand the biocompatibility of Polypyrrole (PP) with peripheral nerve tissue and to provide experimental evidence for the regeneration of defect neural bridging by PP as nerve bridge. Methods Electrochemical oxidation was used to synthesize PP film on conductive glass and silicone tube. The sciatic nerve of newborn rats was co-cultured with PP material, and the morphological changes were observed under inverted microscope and scanning electron microscope. Results The electrochemical conductivity of PP synthesized by electrochemical oxidation method was good. The PP film of conductive glass was smooth and the micropores were small. Besides the conductive glass, the inner wall of silicone tube could be flocculent, and the micropores were interlaced into mesh. Schwann cells of neural tissue migrated well on a smooth PP surface while the floc surface was relatively poor. Conclusion The in vitro co-culture results suggest that PP has good biocompatibility with peripheral nerve tissue of rats. PP with smooth surface is more likely to migrate nerve cell growth