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目的分析葡萄糖酸锌联合脂溶性维生素Ⅰ支持治疗小儿迁延性腹泻病的疗效及安全性。方法选取2015-06—2016-06于阜新市第二人民医院接受诊疗的84例小儿迁延性腹泻病患儿临床资料,依据医治方法的不同,分设为研究组(42例)与对照组(42例),研究组行葡萄糖酸锌复合脂溶性维生素Ⅰ医治,对照组行葡萄糖酸锌医治,比对两组免疫功能情况、相关临床指标以及不良反应情况。结果研究组IgM以及CD_4~+/CD_8~+指标水平(1.50±0.12)g/L、(1.96±0.27)优于对照组;研究组大便性状、恶心呕吐等临床指标改善时间(2.70±0.52)d、(1.09±0.08)d优于对照组,差异具有统计学意义(P<0.05);两组不良反应情况轻微,对比差异无统计学意义(P>0.05)。结论迁延性腹泻疾病患儿行葡萄糖酸锌复合脂溶性维生素Ⅰ医治可改善各项临床症状,并提高其机体免疫功能。
Objective To analyze the efficacy and safety of zinc gluconate combined with fat-soluble vitamin Ⅰ in the treatment of children with persistent diarrhea. Methods The clinical data of 84 pediatric patients with persistent diarrhea admitted to Second People’s Hospital of Fuxin City from June 2015 to June 2016 were divided into study group (42 cases) and control group (42 cases) according to the different treatment methods Cases), the research group of zinc gluconate fat-soluble vitamin Ⅰ treatment, the control group were treated with zinc gluconate, the immune function than the two groups, the relevant clinical indicators and adverse reactions. Results The levels of IgM and CD_4 ~ + / CD_8 ~ + in study group were significantly higher than those in control group (1.50 ± 0.12) g / L and 1.96 ± 0.27, respectively (2.70 ± 0.52) d, (1.09 ± 0.08) d were better than the control group, the difference was statistically significant (P <0.05). There was no significant difference between the two groups in adverse reactions (P> 0.05). Conclusion The treatment of persistent diarrhea in children with zinc gluconate combined with lipid-soluble vitamin Ⅰ can improve the clinical symptoms and improve their immune function.