【摘 要】
：
AIM: To investigate the effects of morphine dependence and withdrawal on the concentrations of neurosteroids in rat brain. METHODS: A method of simultaneous qua
【机 构】
：
Bathune International Peace Hospital, Hebei Medical University, Shijiazhuang 050082, China
论文部分内容阅读
AIM: To investigate the effects of morphine dependence and withdrawal on the concentrations of neurosteroids in rat brain. METHODS: A method of simultaneous quantification of neurosteroids by gas chromatography-mass spectrometry (GC-MS) had been established. RESULTS: The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG), progesterone (PROG), and pregenenolone sulfate (PREGS) in rats killed 6 h after the last treatment. In contrast, there were no significant effects of morphine dependence on the brain concentrations of allopregnanolone (AP), dihydroepiandrosterone (DHEA), and dihydroepiandrosterone sulfate (DHEAS). Naloxone-induced withdrawal produced a significant increase in the concentrations of PREG, PROG, AP, DHEA, PREGS, and DHEAS as compared with the control group.CONCLUSION: Morphine dependence and withdrawal affected the concentrations of neurosteroids in rat brain,which suggests that endogenous neurosteroids in brain might be related to the development of morphine dependence and withdrawal.
其他文献
本研究是黑龙江省大庆市科学技术计划项目"名贵花卉快速繁殖与万寿菊高产栽培体系研究"的部分内容。 万寿菊是一种重要的色素植物，但目前关于万寿菊施肥和种植密度的研究较
Aim: To identify and classify all potential hemolysin candidates of Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai. Methods: All of thepotenti
以控制大豆绿子叶的两个重叠隐性基因(d_1d_2)为标志基因,研究了花粉给体和受体基因型及两者之间的相对距离对大豆天然异交率的影响。花粉受体和给体以10—80厘米距离在行间
被《新疆日报》评为1984年度好新闻的《农民“企业家”——买买提·纳斯尔》这条消息,全文只有六百五十字。它短小生动,具有鲜明的典型意义和时代特征。墨玉县地处塔克拉玛
采用29个品种(系),设4个密度处理,以裂区设计,对不同品种(系)在不同时期及不同降雨条件下的田间倒伏发生情况进行了系统研究。小麦抽穗后,调查各次降雨引起田间倒伏表现,共计七次。结合降雨量分析倒伏发生情况,结果表明春小麦倒伏主要发生在2个时期,即穗重快速增长期和乳熟末期至蜡熟初期。在本试验所经历的降雨量范围内,没有发现倒伏与降雨量的相关性,降雨只是引起小麦倒伏的诱因之一;各品系在不同密度和生育进程
本研究于2003年至2005年在中国科学院合肥智能所农业信息化重点实验室和安徽农业大学农学系数字农业实验室共同完成。研究课题是国家科技部“863”计划重点资助项目“智能化
文艺记者面对的是一个色彩缤纷的世界。书画出版、歌舞演出、影视播映、文艺论争、创作和鉴赏心态变化,这里面涌动着多少有价值有兴味的信息等待记者去捕捉。一篇好的文艺报
AIM: To identify genes responsive to apoptosis in HL-60 cells treated by homoharringtonine. METHODS: cDNA microarray technology was used to detect gene expressi
Aim: To examine whether the prostaglandins (PGs) pathway is involved in triggering delayed neuroprotection by ischemic preconditioning (IPC) and evaluate the ef
棉纤维加厚发育期是纤维比强度形成的关键时期，棉纤维加厚发育生理特性决定棉纤维比强度的形成。本文以产量和纤维比强度差异显著的棉花品种为材料，于2004～2005年在江苏南京(长江流域下游棉区)大田栽培条件下，研究：(1)棉铃对位叶碳氮比值(C／N)的变异性及与棉铃干物质积累与分配的关系；(2)棉纤维加厚发育相关物质(可溶性糖、蔗糖、β-1，3-葡聚糖和纤维素)变化的基因型差异及与纤维比强度形成的关系