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目的研究骨碎补总黄酮对实验性牙周炎大鼠牙槽骨重建的影响,评价骨碎补总黄酮在抑制牙周炎大鼠牙槽骨吸收方面的作用及机制。方法成功建立SD大鼠牙周炎模型之后,使用完全随机分组方法将大鼠分为正常组、牙周炎组、骨碎补总黄酮组,每组12只。分别灌服生理盐水和骨碎补总黄酮240mg·kg-1·d-1。每组分别在给药后第15、30天各处死6只,采用显微CT对大鼠牙槽骨进行三维重建,评价骨碎补总黄酮对实验性牙周炎大鼠牙槽骨重建作用的影响。结果各时间段骨碎补总黄酮组比牙周炎组牙槽骨丧失程度显著减小(P<0.05),且呈持续改善状态(P<0.05)。给药15天后,骨碎补总黄酮组的牙槽骨相对骨体积、骨小梁厚度均明显高于牙周炎组(P<0.05);骨小梁间隙明显低于牙周炎组(P<0.05);给药30天后,骨碎补总黄酮组的牙槽骨相对骨体积、骨小梁厚度均明显高于牙周炎组(P<0.05);骨表面积体积比、骨小梁间隙明显低于牙周炎组(P<0.05)。骨碎补总黄酮组的骨小梁厚度、骨表面积体积比、骨小梁间隙显示出持续改善状态(P<0.05)。结论补碎骨总黄酮能够促进牙槽骨改建,对牙周炎治疗具有一定辅助作用。
Objective To study the effect of total flavonoids of Rhizoma Drynariae on alveolar bone remodeling induced by experimental periodontitis in rats and evaluate the mechanism and mechanism of total flavonoids of Rhizoma Drynariae in inhibiting alveolar bone resorption in periodontitis rats. Methods After successfully establishing the model of periodontitis in SD rats, rats were divided into normal group, periodontitis group and total flavone group of drynaria with 12 rats in each group by a completely randomized method. The rats were dredged with 240 mg · kg-1 · d-1 of total flavonoids of normal saline and Rhizoma Drynariae respectively. Six rats were sacrificed on the 15th and 30th day after the administration respectively. Microalbumin (CT) was used to reconstruct the rat alveolar bone to evaluate the effect of the total flavonoids of Rhizoma Drynariae on alveolar bone remodeling in experimental periodontitis rats Impact. Results The loss of alveolar bone in DRBF group was significantly lower than that of periodontitis group at each time point (P <0.05), and showed a continuous improvement (P <0.05). After 15 days of administration, the relative volume of alveolar bone and trabecular thickness in total flavonoids of Rhizoma Drynariae were significantly higher than those in periodontitis group (P <0.05), and the trabecular gap was significantly lower than that in periodontitis group (P <0.05). After 30 days of administration, the relative volume of alveolar bone and trabecular thickness in total flavone of Rhizoma Drynariae were significantly higher than those in periodontitis group (P <0.05). The ratio of bone surface area to volume, trabecular bone space Significantly lower than the periodontitis group (P <0.05). The total trabecular bone thickness, bone surface area to volume ratio, and trabecular bone space of the total flavone group of NBR were improved continuously (P <0.05). Conclusion The total flavone flavoring can promote alveolar bone remodeling, and it has some auxiliary effects on the treatment of periodontitis.