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本文报告13例罕见的中枢神经系统原发性淋巴瘤临床病理和免疫组织化学结果。男性7例,女性6例,平均年龄47岁。病理组织学诊断按Lukes和Collins分类法。免疫组织化学染色选用6种免疫标记物。每种标记物总的阳性率为LCA69.23%,全T30.77%,全B细胞7.69%,λ轻链76.92%,α1ACT100%,K轻链均阴性。本文提出脑淋巴瘤可能来源于原始的干细胞,具有向多种细胞分化的能力,并讨论了其组织发生、临床特点和鉴别诊断。
This article reports 13 cases of rare primary central nervous system lymphoma clinicopathological and immunohistochemical results. 7 males and 6 females, with an average age of 47 years. Pathological diagnosis by Lukes and Collins classification. Immunohistochemical staining using six kinds of immune markers. The total positive rate of each marker was 69.23% for LCA, 30.77% for whole T, 7.69% for whole B cells, 76.92% for λ light chain, 100% for α1ACT, and negative for K light chain. This article suggests that brain lymphoma may originate from the primitive stem cells, have the ability to differentiate into many kinds of cells, and discuss its histogenesis, clinical features and differential diagnosis.