论文部分内容阅读
曲唑酮是最早开发的非三环类抗抑郁药之一,选择性地抑制脑神经突触对5-羟色胺的再摄取,同时对5-羟色胺的前体5-羟色氨酸所诱发的行为改变有加强作用。曲唑酮有微弱的阻止去甲肾上腺素重吸收的作用,但对多巴胺、组胺和乙酰胆碱无作用,亦不抑制脑内单胺氧化酶的活性,因此对心血管系统毒性小,无抗胆碱作用,常使用于老年或伴有心血管疾病的抑郁症病人。曲唑酮对心脏无影响,但能引起血压下降,此作用与剂量有关。曲唑酮能
Trazodone is one of the earliest non-tricyclic antidepressants that selectively inhibits the reuptake of serotonin by brain synapses while stimulating serotonin 5-hydroxytryptophan Behavioral changes have a reinforcing effect. Trazodone has a weak effect of preventing norepinephrine reabsorption but has no effect on dopamine, histamine and acetylcholine, and does not inhibit the activity of monoamine oxidase in the brain. Therefore, trazodone has little toxicity on the cardiovascular system and no anticholinergic effect, Often used in elderly or with depression in patients with cardiovascular disease. Trazodone has no effect on the heart, but can cause blood pressure drops, the role of dose-related. Trazodone can