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本文运用微量酶联免疫间接法对27例系统性红斑狼疮(SLE)患者的41份血浆标本进行抗巨细胞病毒(HCMV)IgG和IgM的测定。结果表明抗HCMV-IgG的阳性率在SLE组和正常对照组分别为92.7％和89.5％,几乎无差别;活动期SLE组抗HCMV-IgG的几何平均滴度(GMT)明显高于对照组(P<0.01),而非活动期SLE组抗HCMV-IgG水平与对照组差别不显著(P>0.05)。抗HCMV-IgM的阳性率在活动期SLE组为33.3％,非活动期SLE组为40.0％,均显著高于对照组(10.53％);但各组在抗HCMV-IgM的滴度上差异均无显著性。上述结果表明,SLE和HCMV感染有一定程度的相关性,本文从某些方面论述了产生这种相关性的可能原因以及这种相关性对SLE的发生发展可能产生的影响
In this study, 41 plasma samples from 27 patients with systemic lupus erythematosus (SLE) were tested for anti-cytomegalovirus (HCMV) IgG and IgM using indirect enzyme-linked immunosorbent assay. The results showed that the positive rate of anti-HCMV-IgG in the SLE group and the normal control group were 92.7% and 89.5% respectively, with almost no difference. The geometric mean titer (GMT) of anti-HCMV-IgG in the active SLE group was significantly higher than that of the control group P <0.01), while the level of anti-HCMV-IgG in inactive SLE group was not significantly different from that in control group (P> 0.05). The positive rates of anti-HCMV-IgM were 33.3% in active SLE group and 40.0% in inactive SLE group, all of which were significantly higher than that of control group (10.53%); however, the titer of anti-HCMV- No significant. The above results indicate that there is a certain degree of correlation between SLE and HCMV infection. This article discusses in some aspects the possible causes of this association and the possible impact of this association on the development and progression of SLE