目的探讨普罗布考联合阿托伐他汀治疗大动脉粥样硬化性脑梗死临床疗效。方法选取2013年2月—2015年2月邢台市第三医院收治的大动脉粥样硬化性脑梗死患者100例,随机分为对照组和治疗组,每组各50例。对照组睡前口服阿托伐他汀钙片,20 mg/次,1次/d。治疗组在对照组基础上口服普罗布考片,500 mg/次,2次/d。两组均治疗12周。观察两组的临床疗效,比较两组抗氧化能力、血管内皮功能和颈动脉内膜中层厚度(IMT)和斑块面积的情况。结果治疗后,对照组和治疗组的总有效率分别为72.0%、88.0%,两组比较差异有统计学意义(P<0.05)。治疗后,两组氧化低密度脂蛋白(ox-LDL)和丙二醛(MDA)均显著下降,而超氧化物歧化酶(SOD)均显著上升,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组内皮素-1(ET-1)均显著下降,而一氧化氮(NO)和反应性充血后血管内径变化率(FMD)均显著上升,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组IMT和斑块面积均显著下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论普罗布考联合阿托伐他汀治疗大动脉粥样硬化性脑梗死具有较好的疗效,可改善机体应激反应和血管内皮功能,减少IMT和斑块面积,具有一定的临床推广应用价值。 Objective To investigate the clinical efficacy of probucol combined with atorvastatin in treating atherosclerotic cerebral infarction. Methods 100 patients with atherosclerotic cerebral infarction admitted to the Third Hospital of Xingtai City from February 2013 to February 2015 were randomly divided into control group and treatment group, 50 cases in each group. Control group before oral sodium atorvastatin tablets, 20 mg / time, 1 / d. The treatment group on the basis of the control group, oral probucol tablets, 500 mg / time, 2 times / d. Both groups were treated for 12 weeks. The clinical efficacy of the two groups was observed. The antioxidant capacity, endothelial function and carotid intima-media thickness (IMT) and plaque area were compared between the two groups. Results After treatment, the total effective rate of the control group and the treatment group was 72.0% and 88.0%, respectively, with significant difference between the two groups (P <0.05). After treatment, the levels of ox-LDL and MDA were significantly decreased, while the superoxide dismutase (SOD) were significantly increased in both groups (P <0.05). The difference was statistically significant before and after treatment P <0.05). The improvement of these indexes in the treatment group was obviously better than that in the control group. There was significant difference between the two groups (P <0.05). After treatment, both endothelin-1 (ET-1) were significantly decreased, and the nitric oxide (NO) and reactive hyperemia after vascular diameter change rate (FMD) were significantly increased in the same group before and after treatment were statistically significant (P <0.05). The improvement of these observation indexes in the treatment group was obviously better than that in the control group, the difference between the two groups was statistically significant (P <0.05). After treatment, IMT and plaque area decreased significantly in both groups, with statistical significance (P <0.05) before and after treatment in the two groups; and the decrease of these indexes in the treatment group was obviously better than that in the control group. There was significant difference between the two groups Statistical significance (P <0.05). Conclusions Probucol combined with atorvastatin has a good curative effect in treating atherosclerotic cerebral infarction, which can improve the body stress response and endothelial function, reduce the IMT and plaque area, and has certain clinical application value.