论文部分内容阅读
[目的]探讨低剂量卡托普利和辛伐他汀对大鼠糖尿病肾病的预防效果。[方法]2009年,将体重200 g的80只S-D大鼠随机分为5组,每组16只,分别为正常对照组(E组)、糖尿病对照组(D组)、3个药物干预组,干预组糖尿病造模后分别给予其低剂量卡托普利(A组)、辛伐他汀(B组)、卡托普利和辛伐他汀(C组),2个月后观察临床表现、血生化指标与免疫组织化学指标、形态学指标。[结果]大鼠24 h尿白蛋白排泄量,1个月时A组、B组、C组、D组均高于E组,A、B、C组均低于D组(P<0.01);2个月时,A组、B组、C组、D组均高于E组(P<0.01),A组、B组、C组均低于D组(P<0.01或P<0.05)。血糖浓度,A、B、C、D组均高于E组(P<0.01);甘油三酯浓度,A、B、C组、D组均高于E组(P<0.01或P<0.05);总胆固醇浓度,5组间的差异无统计学意义(P>0.05);低密度胆固醇浓度,B、D组均高于E组(P<0.01),A组、C组与E组的差异均无统计学意义(P>0.05);尿素氮浓度,A、B、C、D组均高于E组(P<0.01);肌酐浓度,A、B、C组均低于E组(P<0.01),D组与E组的差异无统计学意义(P>0.05)。[结论]低剂量卡托普利、辛伐他汀及二者联合使用对糖尿病肾病有预防作用,但联合用药并不比单独应用更好。
[Objective] To investigate the preventive effects of low-dose captopril and simvastatin on diabetic nephropathy in rats. [Methods] In 2009, 80 SD rats weighing 200 g were randomly divided into 5 groups (n = 16), which were normal control group (E group), diabetic control group (D group), 3 drug intervention groups , The intervention group were given low-dose captopril (group A), simvastatin (group B), captopril and simvastatin (group C) respectively after 2 months. After 2 months, the clinical manifestations, blood Biochemical and immunohistochemical indicators, morphological indicators. [Results] The 24 h urinary albumin excretion of rats in group A, group B, group C and group D at 1 month were significantly higher than those in group E, and those at group A, B and C were significantly lower than those at group D (P <0.01) (P <0.01); Group A, B and C were lower than those in Group D at 2 months (P <0.01 or P <0.05) . The levels of triglyceride in group A, B, C and D were significantly higher than those in group E (P <0.01 or P <0.05) (P> 0.05). The concentration of low density cholesterol in group B and D were higher than that in group E (P <0.01), while the difference between group A and group C and group E was not significant (P> 0.05). The concentration of urea nitrogen in group A, B, C and D was higher than that in group E (P <0.01). The levels of creatinine in group A, B and C were lower than those in group E <0.01). There was no significant difference between D group and E group (P> 0.05). [Conclusion] The combination of low-dose captopril, simvastatin and their combination can prevent diabetic nephropathy, but combination therapy is not better than single-dose combination.