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端粒酶的激活与恶性肿瘤发生发展之间存在着密切的关系。有效地抑制端粒酶活性有可能导致肿瘤治疗方面的重大突破。有关端粒酶自身起源及结构的深入研究有助于这一问题的解决。本文对端粒酶的起源、组分、功能调控研究方面的最新进展进行了综述 ,并将端粒酶与肿瘤的关系予以总结和展望
There is a close relationship between the activation of telomerase and the development of malignant tumors. Effective inhibition of telomerase activity may lead to major breakthroughs in cancer treatment. The in-depth study of the origin and structure of telomerase contributes to the solution of this problem. This article reviews recent advances in the study of the origin, composition, and function regulation of telomerase, and summarizes and prospects the relationship between telomerase and tumors.