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目的探讨体重及其构成成分对2型糖尿病(T2DM)患者骨量的影响。方法 DEXA测定131例T2DM患者及89名对照者的瘦体重、总体脂量、全身脂肪含量、全身骨密度(BMD)及骨矿含量(BMC),计算BMI、校正骨矿含量(CBMC),对比两组上述指标,分析体重及其构成成分与骨量关系。结果 T2DM组体重、瘦体重及BMC大于对照组,两组间BMD、CBMC无差异。在T2DM组成员中,体重、瘦体重、总体脂量与骨量呈正相关,全身脂肪含量与骨量呈负相关。结论 T2DM患者骨密度与正常人比较无下降,较高的体重、瘦体重及总体脂量是其骨量保护因素,瘦体重的保护作用更显著。
Objective To investigate the effect of body weight and its components on bone mass in type 2 diabetes mellitus (T2DM). Methods DEXA was used to measure lean body mass, total fat mass, total body fat mass, total body bone mineral density (BMD) and bone mineral content (BMC) in 131 T2DM patients and 89 controls. BMI and bone mineral content (CBMC) Two sets of these indicators, analysis of body weight and composition and bone mass relationship. Results Body weight, lean body mass and BMC in T2DM group were higher than those in control group. No difference was found in BMD and CBMC between two groups. In the T2DM group, body weight, lean body mass, total fat mass were positively correlated with bone mass, while total body fat mass was negatively correlated with bone mass. Conclusions BMD of T2DM patients is not decreased compared with that of normal people. The higher body weight, lean body mass and total fat weight are the protective factors of bone mass, and the protective effect of lean body mass is more significant.