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目的:了解阿尔茨海默病老年患者自评和代评生活质量的差异性，为临床护理人员正确测评其生活质量提供依据。方法:于2019年5—8月采取方便抽样方法，选取山东省千佛山医院、山东省省立医院神经内科门诊就诊的165例阿尔茨海默病老年患者及其主要照顾者为调查对象，采用自行设计的老年人及其主要照顾者一般情况调查表、阿尔茨海默病生活质量量表、中国版失智功能障碍评估量表、蒙特利尔认知量表、简版老年抑郁量表、神经精神症状问卷以及照顾负担量表进行面对面调查。结果:回收有效问卷为150份。阿尔茨海默病老年患者自评生活质量总分为（33.40±2.84）分，代评生活质量总得分为（31.45±3.44）分，差异有统计学意义（n P<0.01）；AD老年患者年龄、受教育程度、合并疾病种类、功能障碍、抑郁状况、照顾负担是自评生活质量的主要影响因素（n P<0.05）；照顾者与老年人关系、照顾者受教育程度、照顾者自评健康状况、日常生活能力、神经精神症状、照顾负担是代评生活质量的影响因素（n P<0.05）。n 结论:阿尔茨海默病老年患者自评和代评生活质量存在差异性，建议通过提高阿尔茨海默病老年患者自评准确度及照顾者测评准确度减少差异，有助于提高阿尔茨海默病老年患者的生活质量。“,”Objective:To understand the differences between the self-rated quality of life (QOL) and caregiver-rated QOL in elderly patients with Alzheimer's disease, and to provide basis for clinical nursing staff to correctly evaluate their QOL.Methods:From May to August in 2019, a total of 150 pairs of elderly patients with Alzheimer's disease and their main caregivers were selected from Department of Neurology of Shandong Provincial Qianfoshan Hospital and Shandong Provincial Hospital as the subjects by convenient sampling method. A face-to-face survey was conducted with the self-designed general information questionnaire for the elderly and their main caregivers, QOL-Alzheimer's Disease Scale (QOL-AD) , Chinese version of the Disability Assessment for Dementia (CDAD) , Montreal Cognitive Assessment (MoCA) , Short version of Geriatric Depression Scale, Geriatric Depression Scale-15 (GDS-15) , Neuropsychiatric Inventory Questionnaire (NPI-Q) , Zarit Burden Interview (ZBI) .Results:150 valid questionnaires were collected.The total score of QOL-AD was (33.40±2.84) , and the total score of caregiver-rated QOL-AD was (31.45±3.44) , the difference was statistically significant (n P< 0.01) ; Age, education level, types of comorbid diseases, cognitive function, depression and burden of care were the main influencing factors of self-rated quality of life (n P< 0.05) ; the relationship between caregivers and the elderly, education level, self-rated health status, daily living ability, neuropsychiatric symptoms and burden of care were the main influencing factors of self-rated quality of life (n P< 0.05) .n Conclusions:There are differences between self-rated QOL and caregiver-rated QOL in the elderly patients with Alzheimer's disease. It is suggested to reduce the differences through improving the accuracy of self-assessment and caregiver assessment, so as to improve QOL of the elderly patients with Alzheimer's disease.