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目的:探讨不同剂量利多卡因对碘缺乏型甲状腺肿全麻切除术后患者恢复质量的影响。方法:采用前瞻性设计，选取2018年4月至2020年4月在烟台业达医院进行碘缺乏型甲状腺肿切除术的患者108例为研究对象。采用随机数字表法将患者分为对照组（生理盐水）、利多卡因A组（1 mg/kg）和利多卡因B组（2 mg/kg），每组36例；分别于麻醉诱导插管后30 min静脉持续泵注相应剂量的利多卡因或等剂量生理盐水。观察3组患者在给药前、术毕即刻、睁眼即刻、拔管即刻、拔管后10 min的舒张压（DBP）、收缩压（SBP）和血糖（GLU）水平变化情况，同时记录患者苏醒躁动程度评分（RS）、镇静评分（Ramsay）、疼痛视觉模拟评分（VAS）及不良反应（呛咳、恶心呕吐、呼吸抑制）的发生情况。结果:在睁眼即刻、拔管即刻及拔管后10 min，对照组、利多卡因A组和利多卡因B组患者DBP（mmHg：77.26 ± 4.85、73.45 ± 4.37、70.94 ± 4.45，83.53 ± 6.19、77.86 ± 5.33、74.14 ± 5.20，73.86 ± 5.73、68.41 ± 5.16、63.09 ± 5.24）、SBP（mmHg：129.17 ± 6.54、121.25 ± 6.07、116.24 ± 5.86，137.48 ± 6.62、129.53 ± 6.38、123.07 ± 6.25，125.65 ± 6.13、117.48 ± 6.09、108.17 ± 6.04）、GLU水平（mmol/L：5.83 ± 0.36、5.37 ± 0.29、5.12 ± 0.26，6.69 ± 0.34、5.84 ± 0.30、5.57 ± 0.27，5.61 ± 0.32、5.25 ± 0.31、4.97 ± 0.28）比较，差异均有统计学意义（n F=17.520、25.755、36.034、41.028、45.525、74.330、10.397、49.756、52.348，n P均< 0.05）；其中，利多卡因A组和利多卡因B组DBP、SBP、GLU水平均低于对照组，且利多卡因B组均低于利多卡因A组（n P均< 0.05）。利多卡因A组和利多卡因B组患者RS、VAS均显著低于对照组，Ramsay均高于对照组（n P均< 0.05）；且利多卡因B组RS、VAS均低于利多卡因A组，Ramsay高于利多卡因A组（n P均< 0.05）。利多卡因A组和利多卡因B组患者呛咳、恶心呕吐发生率均低于对照组（n P均< 0.05）；3组患者均无呼吸抑制发生。n 结论:麻醉诱导后30 min静脉持续泵注2 mg/kg利多卡因，能够维持行碘缺乏型甲状腺肿全麻切除术患者的血压及GLU稳定，有效降低患者苏醒期躁动、疼痛和不良反应，是甲状腺手术患者苏醒舒适的满意剂量。“,”Objective:To explore the effect of different doses of lidocaine on recovery quality of patients with iodine-deficiency goiter after general anesthesia resection.Methods:Using a prospective design, 108 patients who underwent iodine-deficiency goiter resection in Yantai Yeda Hospital from April 2018 to April 2020 were selected as the research subjects. The patients were divided into control group (normal saline), lidocaine group A (1 mg/kg) and lidocaine group B (2 mg/kg) by random number table method, 36 cases in each group. The corresponding dose of lidocaine or the equivalent dose of normal saline was pumped into the vein after anesthesia induction and intubation for 30 minutes. The changes in the diastolic blood pressure (DBP), systolic blood pressure (SBP) and blood glucose (GLU) levels of the three groups were observed before administration, immediately after the operation, immediately after opening the eyes, immediately after extubation, and 10 minutes after extubation; at the same time, arousal and restlessness score (RS), sedation score (Ramsay), visual analogue score (VAS) and adverse reactions(coughing, nausea and vomiting, respiratory depression) occurrence were recorded.Results:At the moment of eye opening, immediately after extubation and 10 minutes after extubation, DBP (mmHg: 77.26 ± 4.85, 73.45 ± 4.37, 70.94 ± 4.45, 83.53 ± 6.19, 77.86 ± 5.33, 74.14 ± 5.20, 73.86 ± 5.73, 68.41 ± 5.16, 63.09 ± 5.24), SBP (mmHg: 129.17 ± 6.54, 121.25 ± 6.07, 116.24 ± 5.86, 137.48 ± 6.62, 129.53 ± 6.38, 123.07 ± 6.25, 125.65 ± 6.13, 117.48 ± 6.09, 108.17 ± 6.04), GLU level (mmol/L: 5.83 ± 0.36, 5.37 ± 0.29, 5.12 ± 0.26, 6.69 ± 0.34, 5.84 ± 0.30, 5.57 ± 0.27, 5.61 ± 0.32, 5.25 ± 0.31, 4.97 ± 0.28) of lidocaine group A and lidocaine group B were significantly lower than those of control group, the difference were statistically significant (n F=17.520, 25.755, 36.034, 41.028, 45.525, 74.330, 10.397, 49.756, 52.348, n P < 0.05); among them, the DBP, SBP and GLU levels of lidocaine group A and lidocaine group B were lower than those of control group, and lidocaine group B was lower than lidocaine group A ( n P < 0.05). The RS and VAS of lidocaine group A and lidocaine group B were significantly lower than those of control group, and Ramsay was higher than that of control group ( n P < 0.05); and the RS and VAS of lidocaine group B were lower than those of lidocaine group A, the Ramsay was higher than that of lidocaine group A ( n P < 0.05). The incidence of coughing, nausea and vomiting in lidocaine group A and lidocaine group B were lower than those in the control group ( n P < 0.05); and there was no respiratory depression in the three groups.n Conclusions:Thrity minutes after induction of anesthesia, continuous pumping of 2 mg/kg lidocaine can maintain blood pressure and GLU of patients undergoing general anesthesia for iodine-deficiency goiter, and effectively reduce restlessness, pain and adverse reactions during the recovery period. It is a satisfactory dose for thyroid surgery patients to wake up and comfortably.