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目的 :探讨随机尿微量白蛋白/肌酐比值(ACR)、血清胱抑素C(Cys-C)水平联合测定对慢性肾病的诊断价值。方法 :选取在我院肾内科确诊为原发性慢性肾病的155例患者,根据尿微量白蛋白(m Alb)结果分为m Alb阴性患者组76例和m Alb阳性患者组79例,对其随机尿ACR、血清Cys-C、血清肌酐(Cr)、血清尿素氮(BUN)等临床资料进行分析,并将结果于36例健康体检者(对照组)进行比较。结果 :两组患者组随机尿ACR与血清Cys-C水平均明显高于健康对照组;m Alb阳性患者随机尿ACR与血清Cys-C水平高于m Alb阴性患者组;两者的单项异常检出率高于血清肌酐(Cr)、尿素氮(BUN),联合检测阳性率亦明显高于单项检测;随机尿ACR与血清Cys-C水平呈显著正相关。结论 :随机尿ACR与血清Cys-C水平与原发性慢性肾病患者的肾损害程度密切相关,两者联合检测更有利于早期发现原发性肾脏损伤。
Objective: To investigate the diagnostic value of the combination of random urine microalbumin / creatinine ratio (ACR) and serum cystatin C (Cys-C) in the diagnosis of chronic kidney disease. Methods: A total of 155 patients with primary chronic kidney disease (NSCLC) diagnosed as nephrology in our hospital were divided into 76 patients with m Alb negative and 79 patients positive with m Alb according to the result of m Alb. Random ACR, serum Cys-C, serum creatinine (Cr), serum urea nitrogen (BUN) and other clinical data were analyzed, and the results in 36 healthy subjects (control group) were compared. Results: The levels of ACR and Cys-C in random urine of patients in both groups were significantly higher than those in healthy controls. The ACR and serum Cys-C levels of random urine in m Alb positive patients were higher than those of m Alb negative patients. The positive rate of combined detection was significantly higher than that of single test. The ACR of random urine had a significant positive correlation with serum Cys-C level. Conclusion: The random ACR and serum Cys-C levels are closely related to the degree of renal damage in patients with primary chronic kidney disease. The combined detection of both is more beneficial to the early detection of primary kidney damage.