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山莨菪碱(654—2)是一种抗胆碱药,临床主要用于抗休克和解除平滑肌痉挛,经过多年的临床应用,陆续发现本品还具有不少其它用途,现就其在呼吸系统疾病中的应用分述如下:1 咳嗽(支气管炎、上呼吸道感染引起) 王金斗,王艳珺用山莨菪碱治疗剧烈咳嗽100例(上呼吸道感染45例,急性支气管炎38例,慢性支气管炎17例),结果:显效61例,有效34例,总有效率95.0％。方法:山莨菪碱 10mg,tid,po,一般3d～6d。有细菌感染者选择适当的抗菌药。机制:山莨菪碱抑制迷走神经兴奋性,切断或削弱咳嗽的神经反射过程,呈现镇咳作用。山莨菪碱还能改善呼吸道微循环,有利于呼吸道病损修复;抑制呼吸道腺体的过度分泌,适当减少呼吸道分泌物,从而减轻对呼吸道粘膜的刺激;扩张支气管,有利于呼吸道的通畅,都对消除或减轻咳嗽有利。
Anisodamine (654-2) is an anticholinergic drug which is mainly used for anti-shock and relieving spasm of smooth muscle. After years of clinical application, it has been found that this product also has many other uses, and now it is used in respiratory diseases The application is described as follows: 1 cough (bronchitis, upper respiratory tract infection caused by) Wang Jin Dou, Wang Yan Jun with anisodamine treatment of severe cough in 100 cases (45 cases of upper respiratory tract infection, acute bronchitis in 38 cases, chronic bronchitis in 17 cases) Results: 61 cases markedly effective, effective in 34 cases, the total effective rate was 95.0%. Methods: Anisodamine 10mg, tid, po, usually 3d ~ 6d. Bacterial infections choose the appropriate antimicrobial agents. Mechanism: Anisodamine inhibits vagal excitability, cut off or weaken the nerve reflex process of cough, showing antitussive effect. Anisodamine can also improve the airway microcirculation, is conducive to respiratory tract lesions repair; inhibit the secretion of respiratory glands, appropriate to reduce respiratory secretions, thereby reducing the respiratory mucosa stimulation; expansion of the bronchus, is conducive to airway patency, are Eliminating or relieving cough is good.