论文部分内容阅读
目的 :探讨一氧化氮 (NO)和内皮素 (ET 1)在妊高征发病中的作用及其对胎儿生长发育的影响。方法 :采用比色法和放射免疫法对正常妊娠妇女 2 7例 ,正常未孕组 2 0例 (对照组 ) ,妊高征患者 5 2例 (妊高征组 )的血浆、新生儿脐血 (2 3例 )中NO和ET 1水平进行检测。结果 :妊高征组ET 1水平较对照组高 ,以中重度妊高征组增高显著 (P <0 .0 1)。NO水平较对照组低 ,差异有显著性 (P <0 .0 5 )。在中重度妊高征者中 ,合并胎儿生长发育迟缓组 (IUGR)母血和新生儿脐血ET 1水平明显高于未合并IUGR组。NO水平则明显低于未合并IUGR组。结论 :NO的合成、释放减少与内皮细胞损伤ET 1释放增加 ,在妊高征发病中起重要作用。并且影响胎儿的生长发育。
Objective: To investigate the role of nitric oxide (NO) and endothelin (ET 1) in the pathogenesis of pregnancy induced hypertension and their effects on fetal growth and development. Methods: The colorimetry and radioimmunoassay were used to detect the plasma levels of neonatal cord blood in 27 normal pregnant women, 20 normal pregnant women (control group), 52 PIH patients (pregnancy induced hypertension group) (23 cases) NO and ET 1 levels were detected. Results: The ET 1 level in PIH group was higher than that in control group, and significantly increased in moderate and severe PIH group (P <0.01). The level of NO was lower than the control group (P <0.05). In moderate-severe PIH, the level of ET-1 in maternal and neonatal combined with fetal growth retardation group (IUGR) was significantly higher than that in non-combined IUGR group. NO levels were significantly lower than those without IUGR group. CONCLUSION: The decrease of NO synthesis and release and the increase of endothelial ET 1 release play an important role in the pathogenesis of PIH. And affect the growth and development of the fetus.