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本文旨在观察口服７－甲基异炔诺酮（Ｏｒｇ ＯＤ１４）对更年期妇女心率变异性的影响。方法：依应用７－甲基异炔诺酮治疗与否将６６例更年期妇女分为试验组 （３１例）和对照组 （３６例），于治疗开始前和服药 ４个月后分别进行 ２４ｈ动态心电图心率变异性检查。结果：与初次检查结果相比，试验组口服７甲基异炔诺酮４个月后心率变异性各项指标均有明显改善（Ｐ＜０．０５），而对照组无明显改变（Ｐ＞０．０５）。试验组心率变异性各项指标在用药前与平均心率周期均呈负相关（Ｐ＜０．０５），用药４个月后无明显相关。结论：提示口服７－甲基异炔诺酮可改善更年期妇女的心率变异性。
This article aims to investigate the effect of oral administration of Org OD14 on heart rate variability in menopausal women. Methods: Sixty-six cases of menopausal women were divided into experimental group (n = 31) and control group (n = 36) according to whether or not 7-methyl-norethindrone was used for treatment. ECG heart rate variability check. Results: Compared with the initial test results, the indexes of heart rate variability in the test group were significantly improved after oral administration of 7-norethindrone (P <0.05), but there was no significant change in the control group (P> 0.05). The indexes of heart rate variability in the experimental group were negatively correlated with the average heart rate cycle before treatment (P <0.05), and no significant correlation was found after 4 months of treatment. Conclusion: It is suggested that oral administration of 7-methyl-norethindrone may improve heart rate variability in menopausal women.