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在儿童时期某些小儿对病毒和细菌非常容易感染,原因之一可能是干扰素(IFN)系统缺陷。此系统包括IFN诱导剂、IFN生成细胞,各型IFN及靶细胞;后者包括T和B淋巴细胞,单核巨噬细胞和自然杀伤细胞等。近来有人自4/29例易感小儿白细胞中发现,在体外用病毒刺激白细胞后出现IFN-α生成缺陷。又有人报告,一小儿持续EB病毒感染伴有选择性IFN-γ生成缺陷。本文对频发呼吸道感染小儿的IFN可能有缺陷这一问题进行了探讨。本组28个病例,年龄10个月～10岁,中位数3.5岁。病例A组7例系反复上呼吸道感染者;病例B组16例系反复中耳炎者;病例C组5例主要为下呼吸道感染者;并设立了对照组。IFN的抗病毒活性是以常规的细胞病变效应抑制法测定的。结果在体外,外周血单核白细胞(PBLs)产
Some children may be very susceptible to viruses and bacteria during childhood, and one of the reasons may be interferon (IFN) system deficiencies. This system includes IFN inducer, IFN-producing cells, various types of IFN and target cells; the latter including T and B lymphocytes, monocytes and natural killer cells. Recently, it has been found in 4/29 cases of susceptible pediatric leukocytes that IFN-α production defects occur after in vitro stimulation of leukocytes with the virus. It has also been reported that a child with persistent EB virus infection with selective IFN-γ production defects. This article explores the possible deficiencies of IFN in children with recurrent respiratory infections. The group of 28 cases, aged 10 months to 10 years, the median 3.5 years. In group A, 7 cases were recurrent upper respiratory tract infection; 16 cases in group B were patients with recurrent otitis media; 5 cases in group C were mainly patients with lower respiratory tract infection; and a control group was established. The antiviral activity of IFN is measured by conventional cytopathic effect inhibition. Results In vitro, peripheral blood mononuclear cells (PBLs) were produced