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目的探讨电化学发光法(ECLI)与放射免疫法(RIA)检测血清促甲状腺素受体抗体(TRAb)对毒性弥漫性甲状腺肿的诊断价值。方法选取毒性弥漫性甲状腺肿患者98例(A组)及健康体检者60例(B组),分别采用ECLI与RIA测定其TRAb水平,分析对毒性弥漫性甲状腺肿的诊断效能。结果 ECLI与RIA检测均显示,A组血清TRAb水平均高于B组(P<0.01)。ECLI和RIA检测TRAb诊断毒性弥漫性甲状腺肿的灵敏度和特异度差异均无统计学意义(38.8%vs.32.7%和86.7%vs.85.0%)(χ~2=0.80、0.07,P>0.05)。结论 ECLI和RIA检测TRAb对毒性弥漫性甲状腺肿有较相近的诊断效能;ECLI方法操作简便,更适合临床检验需要。
Objective To investigate the diagnostic value of serum thyrotropin receptor antibody (TRAb) by electrochemiluminescence (ECLI) and radioimmunoassay (RIA) in the diagnosis of diffuse toxic goiter. Methods A total of 98 patients with diffuse toxic goiter (group A) and 60 healthy people (group B) were enrolled in this study. The levels of TRAb were measured by ECLI and RIA, respectively, and the diagnostic efficacy of diffuse toxic goiter was analyzed. Results Both ECLI and RIA showed that serum TRAb level in group A was higher than that in group B (P <0.01). The sensitivity and specificity of ECLI and RIA for detecting TRAb were not statistically significant (χ ~ 2 = 0.80, 0.07, P> 0.05) . Conclusion ECLI and RIA TRAb detection of toxic diffuse goiter have similar diagnostic efficacy; ECLI method is simple, more suitable for clinical testing needs.