论文部分内容阅读
本品系-17α-乙炔睾酮的衍生物,具有强抗促性腺激素和弱雄激素作用,国外于1963年合成,1971年应用于临床,结果证实其治疗子宫内膜异位症效果良好,可大剂量长期应用,安全范围大,副反应小,被收入美国药典第20版和21版。国内由上海第十二制药厂、扬州制药厂先后研制成功,并已投产应市。药理研究认为,本品由于在雄烷A环上引入了异噁唑环,故男性激素较弱,而具有选择性抑制促性腺
This strain of -17α-ethynone testosterone derivatives, with strong anti-gonadotropin and weak androgen, synthesized in 1963 abroad, 1971 for clinical use, the results confirmed that the treatment of endometriosis is good, can be Long-term use of high-dose, safe range, side effects, income is the United States Pharmacopeia 20th edition and 21 edition. Domestic by the twelfth pharmaceutical factory in Shanghai, Yangzhou Pharmaceutical Factory has successfully developed and has been put into operation should be the city. Pharmacological studies believe that the goods due to the introduction of isoxazole ring in the A ring of androstane, so the male hormone is weak, and selectively inhibit the gonads