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[目的]观察舒血宁注射液对急性胰腺炎(AP)患者氧化应激水平的影响。[方法]79例AP患者随机分成治疗组(41例)和对照组(38例),对照组给予AP常规治疗,治疗组在此基础上予舒血宁注射液20ml稀释后静脉注射,1次/d,共10d,观察治疗前后疗效及氧化应激水平的变化。[结果]治疗前,治疗组及对照组血清IL-6、TNF-α、SOD、MDA水平及CTSI、APACHEⅡ评分比较,差异无统计学意义。治疗后,治疗组血清IL-6、TNF-α、MDA水平及CTSI、APACHEⅡ评分与对照组比较明显降低(P<0.01,P<0.05),而血清SOD则显著升高(P<0.01)。相关性分析表明:血清SOD水平与血清IL-6、TNF-α水平及CTSI、APACHEⅡ评分均呈明显负相关(r分别为-0.720、-0.538、-0.422、-0.661,P<0.01);血清MDA水平与血清IL-6、TNF-α水平及CTSI、APACHEⅡ评分均呈明显正相关(r分别为0.505、0.796、0.473、0.809,P<0.01)。[结论]舒血宁注射液联合常规疗法临床疗效明显优于单用常规疗法,其机制可能与其抗氧化,清除氧自由基的作用有关。
[Objective] To observe the effect of Shuxuening injection on oxidative stress in patients with acute pancreatitis (AP). [Method] The 79 patients with AP were randomly divided into treatment group (41 cases) and control group (38 cases). The control group was given AP routine treatment. On the basis of this, the treatment group was given intravenous injection of Shuxuening injection 20ml diluted, / d, a total of 10d, observed before and after treatment efficacy and changes in the level of oxidative stress. [Results] There was no significant difference in serum IL-6, TNF-α, SOD, MDA levels and CTSI, APACHEⅡ scores before treatment in treatment group and control group. After treatment, the levels of serum IL-6, TNF-α, MDA, CTSI and APACHEⅡ in the treatment group were significantly lower than those in the control group (P <0.01, P <0.05), while the serum SOD was significantly increased (P <0.01). Correlation analysis showed that the level of serum SOD was negatively correlated with the level of serum IL-6 and TNF-α and CTSI and APACHEⅡ (r = -0.720, -0.538, -0.422, -0.661, respectively; P <0.01) MDA levels were positively correlated with serum IL-6 and TNF-α levels and CTSI and APACHEⅡ scores (r = 0.505,0.796,0.473,0.809, P <0.01). [Conclusion] The clinical curative effect of Shuxuening injection combined with conventional therapy is better than that of conventional therapy alone. The mechanism may be related to the anti-oxidation and scavenging of oxygen free radicals.