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目的 探讨男性不育的发病机理。 方法 扫描电镜下观察正常生育男性 4 0个精子 ,不育男性 6 0个精子 ,对精子顶体结构进行对照分析。 结果 不育症精子环状沟模糊者占 6 6 .7%(40 /6 0 ) ,呈锯齿状者占 6 5 .0 % (39/6 0 ) ,而生育精子分别占 10 .0 % (4/40 )和 5 .0 % (2 /40 ) ,两组比较差别有显著性意义 ,P <0 .0 5。不育顶体占头部比例为 (70 .0± 8.0 ) % ,大于正常生育精子的 (5 7.7%± 6 .4 ) % ,P <0 .0 5。顶体膜不完整者不育组占 70 .0 % (42 /6 0 ) ,生育组占 2 2 .5 % (9/40 ) ;表面粗糙者不育组占 6 8.33% (41/6 0 ) ,生育组占 2 0 .0 % (8/40 ) ;表面有颗粒粘附者不育组占 6 5 .0 % (39/6 0 ) ,生育组为 2 7.5 % (11/40 ) ;差别均有显著性意义 ,P <0 .0 1。 结论 精子顶体结构异常是导致男性不育的原因之一。
Objective To investigate the pathogenesis of male infertility. Methods Scanning electron microscopy was used to observe the sperm motility of 40 normal male fertile men and 60 male infertile men. Results Infertility patients with annular ditch fuzzy ambiguity accounted for 6.67% (40/60), jagged accounted for 65.5% (39/60), while fertility sperm accounted for 10.0% ( 4/40) and 5 .0% (2/40), respectively, with significant difference between the two groups (P <0.05). The proportion of infertile acrosome in the head was (70.0 ± 8.0)%, which was higher than that in normal fertility sperm (5 7.7% ± 6.4%), P <0.05. The infertile patients with incomplete acrosome membrane accounted for 70.0% (42/60), fertile group accounted for 22.5% (9/40), and those with rough surface accounted for 6 8.33% (41/60) ), The fertility group accounted for 20.0% (8/40), while those with surface adhesion of particles on the surface were 65.0% (39/60) in the infertility group and 2 7.5% (11/40) in the fertility group. The difference was significant, P <0. Conclusion Sperm acrosome structural abnormalities are one of the causes of male infertility.