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目的探讨68例白血病患者血小板抗体的产生与血小板输注次数的关系;血小板输注效果与血小板抗体之间的关系。方法检测68例白血病患者单采血小板输注前后外周血小板计数;以24h CCI值判断血小板输注效果;血小板抗体筛查采用固相凝集法。结果 68例输注单采血小板的患者中共检出抗体阳性13例,阳性率为19.1%,对照组阳性率2.8%,差异具统计学意义;血小板输注次数>8次时,血小板抗体的阳性率为(53.3%)分别与输注次数<3次组(抗体阳性率8.3%)和输注3-8次组(抗体阳性率10.3%)比较,差异均具统计学意义(P<0.05);血小板抗体阴性患者的血小板输注无效率(32.7%)与血小板抗体阳性患者的输注无效率(69.2%)比较,差异具统计学意义(P<0.05)。结论随着血小板输注次数的增多血小板抗体检出率明显增高,与输注次数成正相关;血小板抗体阳性与血小板输注无效有相关性。
Objective To investigate the relationship between platelet antibody production and platelet transfusion in 68 leukemia patients and the relationship between platelet transfusion and platelet antibodies. Methods Peripheral blood platelet counts were measured before and after apheresis in 68 patients with leukemia. The platelet transfusion was evaluated by 24h CCI value. The platelet antibody was detected by solid phase agglutination. Results Among the 68 patients with single platelet transfusion, 13 were positive for the antibody, the positive rate was 19.1%, the positive rate was 2.8% in the control group. The difference was statistically significant. The platelet antibody was positive when the platelet transfusion number was> 8 (53.3%) were significantly different from those of patients who received infusion less than 3 times (antibody positive rate was 8.3%) and infusion rate was 3-8 times (antibody positive rate was 10.3%), the difference was statistically significant (P <0.05) ; Platelet-negative patients with platelet transfusion inefficiency (32.7%) and platelet-positive patients infusion inefficiency (69.2%), the difference was statistically significant (P <0.05). Conclusions With the increase of platelet transfusion, the detection rate of platelet antibody is significantly increased, which is positively correlated with the number of infusion. The positive of platelet antibody is correlated with the ineffectiveness of platelet transfusion.