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目的探讨分析乙肝病毒(HBV)携带载量对妊娠期糖尿病(GDM)患者妊娠结局的影响。方法选取2011年1月至2013年6月门诊孕检及住院分娩的孕妇18 985例,其中乙肝病毒携带者合并GDM患者386例,携带者中病毒载量阳性合并GDM患者168例设为A1组,病毒载量阴性者合并GDM患者218例为A2组,非乙肝病毒携带者合并GDM患者398例为B组,分别比较B组及A1、A2组的妊娠结局及对胎儿的影响情况。结果各组在早产、剖宫产、产后出血、胎龄和新生儿窒息等方面比较差异无显著性(P>0.05);B组产后出血量为250.27±10.42 ml,低于A1组320.58±10.31 ml和A2组310.42±9.46 ml,差异有统计学意义(P<0.05);A1组和A2组新生儿体质量和产后出血量比较差异无显著性(P>0.05)。结论非乙肝病毒携带者合并GDM患者产后出血量较少,乙肝病毒(HBV)携带载量水平不同对妊娠期糖尿病的妊娠结局没有影响。
Objective To investigate the influence of HBV carrying capacity on pregnancy outcome in gestational diabetes mellitus (GDM). Methods From January 2011 to June 2013, 18 985 pregnant women in outpatient pregnancy test and hospital delivery were enrolled. Among them, 386 cases of hepatitis B virus carriers with GDM and 168 cases of carriers with positive GDM were enrolled as group A1 , 218 patients with negative GAV combined with viral load were selected as Group A2, 398 patients with non-HBV infection combined with GDM were selected as Group B, and the pregnancy outcomes and the effects on fetus were compared between Group B and Groups A1 and A2 respectively. Results There was no significant difference in preterm birth, cesarean section, postpartum hemorrhage, gestational age and neonatal asphyxia between groups (P> 0.05). The postpartum hemorrhage volume in group B was 250.27 ± 10.42 ml, which was lower than that in group A1 320.58 ± 10.31 ml and A2 group was 310.42 ± 9.46 ml, the difference was statistically significant (P <0.05). There was no significant difference in neonatal weight and postpartum hemorrhage between A1 and A2 (P> 0.05). Conclusion Non-hepatitis B virus carriers with GDM have less postpartum hemorrhage and different levels of HBV carriers have no effect on pregnancy outcome in gestational diabetes mellitus.