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Female Wister rats aged 8 weeks were randomly divided into sham operation group,ovariectomized(OVX)control group,and 2 OVX groups fed with soy isoflavone crude extract supplementation.The rats had free access to high fat diet and water for 9 weeks.No significant difference was found in body weight(BW),total abdominal fat,food intake and food utilization rate between OVX control group and 2 OVX groups.However,the fasting blood glucose and blood lipid levels were significantly higher in 2 OVX groups than in OVX control group(P<0.05).Intraperitoneal glucose tolerance test(IGTT)showed that the area under AUC was smaller in 2 OVX groups than in OVX control group(P<0.05).These findings showed that soy isoflavone crude extract supplementation can improve glucose tolerance and prevent high fat diet-induced insulin resistance in ovariectomized rats.
Female Wister rats aged 8 weeks were randomly divided into sham operation group, ovariectomized (OVX) control group, and 2 OVX groups fed with soy isoflavone crude extract supplementation. The rats had free access to high fat diet and water for 9 weeks. No significant difference was found in body weight (BW), total abdominal fat, food intake and food utilization rate between OVX control group and 2 OVX groups. However, the fasting blood glucose and blood lipid levels were significantly higher in 2 OVX groups than in OVX control group (P <0.05) .Intraperitoneal glucose tolerance test (IGTT) showed that the area under AUC was smaller in 2 OVX groups than in OVX control group (P <0.05). These findings showed that the soy isoflavone crude extract supplementation can improve glucose tolerance and prevent high fat diet-induced insulin resistance in ovariectomized rats.