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目的:研究补肾活血中药对帕金森病(PD)患者脑内神经递质水平的影响。方法:采用双盲设计,将60例PD患者随机分成治疗组30例和对照组30例。两组均以西药为基础治疗,其中治疗组加吸补肾活血中药,对照组加吸安慰剂,每日2次。两组患者均以3个月为治疗观察期,疗程结束后带药随访6个月观察。采用脑电超慢涨落图(EFG)观察PD患者脑内乙酰胆碱(Ach)和多巴胺(DA)水平在入组时及治疗3、6、9个月后的变化。结果:对照组DA值在治疗9个月中逐渐下降,Ach逐渐增高,但差异无统计学意义(P>0.05)。治疗组无论在治疗观察期还是随访观察期中,DA数值都呈上升趋势,且具有统计学意义(P<0.05)。Ach水平未见明显变化(P>0.05)。研究过程中未发现明确不良反应。结论:PD患者脑DA水平随病情进展逐渐下降,Ach水平呈增高趋势。补肾活血中药能升高PD患者脑内DA水平,且疗效稳定。
Objective: To study the effects of Bushen Huoxue Chinese medicine on neurotransmitter levels in brain of patients with Parkinson’s disease (PD). Methods: Sixty patients with PD were randomly divided into treatment group (n = 30) and control group (n = 30) by double-blind design. Both groups were treated with western medicine, in which the treatment group plus traditional Chinese medicine and kidney Huoxue medicine, the control group plus inhalation of placebo, 2 times a day. Two groups of patients were treated for 3 months observation period, after the end of treatment with drug 6-month follow-up. The changes of acetylcholine (Ach) and dopamine (DA) levels in the brains of PD patients at the time of 3 and 6, and 9 months of treatment were observed by EEG (EEG). Results: In the control group, the DA value decreased gradually in 9 months and Ach gradually increased, but the difference was not statistically significant (P> 0.05). In the treatment group, the DA values showed an upward trend both in the treatment observation period and the follow-up observation period, with statistical significance (P <0.05). Ach level no significant change (P> 0.05). No clear adverse reactions were found during the study. Conclusion: The level of brain DA in patients with PD gradually decreases with the progression of the disease, and the level of Ach shows an increasing trend. Bushenhuoxue traditional Chinese medicine can increase the brain DA levels in patients with PD, and the effect is stable.