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观察口服氨茶碱治疗的支气管哮喘患者６４例，在加服硫氮酮前后血清氨茶碱浓度的变化及临床表现。结果显示，加用硫氮酮后平均血清氨茶碱浓度增加了０．２％（Ｐ＞０．０５），ＦＥＶ＿１增加了９．２％（Ｐ＜０．０１），ＰａＯ＿２增加了５．３％（Ｐ＜０．０１），ＰａＣＯ＿２下降了７．１％（Ｐ＜０．０１），临床总有效率增加了２５％（Ｐ＜０．０１）。提示加用硫氮酮后未见血清氨茶碱显著增高及其相应的临床症状，两药合用可提高临床疗效；坦在刚开始合用时，应注意血压下降的变化。
To observe the oral aminophylline treatment of bronchial asthma in 64 patients, before and after the administration of diltiazem serum aminophylline concentration changes and clinical manifestations. The results showed that mean serum aminophylline concentration increased by 0.2% (P> 0.05), FEV_1 increased by 9.2% (P <0.01) and PaO_2 increased by 5.3% % (P <0.01), PaCO_2 decreased by 7.1% (P <0.01), and clinical total effective rate increased by 25% (P <0.01). Prompt use of diltiazem after no significant increase in serum aminophylline and its corresponding clinical symptoms, combined use of two drugs can improve clinical efficacy; Tan at the beginning of combination, we should pay attention to changes in blood pressure.